Sorting Nexin 3 Antikörper

Produktnummer ABIN7119361

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Sorting Nexin 3 in ELISA, WB und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Sorting Nexin 3 Antikörper (ABIN7119361)

Target: Sorting Nexin 3 (SNX3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sorting Nexin 3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Sorting Nexin 3 Antikörper

Verwendungszweck: SNX3 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: sorting nexin 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Sorting Nexin 3

Target: Sorting Nexin 3 (SNX3)

Andere Bezeichnung: SNX3

Hintergrund:

Synonyms: Sorting nexin-3|Protein SDP3|SNX3

Background: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate(PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate(PtdIns(P4)), phosphatidylinositol 5-phosphate(PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate(PtdIns(3,5)P2)(By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex(CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway(PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel(ENAC) subunits SCNN1A and SCNN1G(By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes(PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes, the function may involve the CSC retromer subcomplex(By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole(SCV) and promotes recruitment of LAMP1 to SCVs(PubMed:20482551).

Molekulargewicht: 16-20 kDa

Gen-ID: 8724

UniProt: O60493